Differential modulation of E. coli mRNA abundance by inhibitory proteins that alter the composition of the degradosome
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gao, Junjun | - |
dc.contributor.author | Lee, Kangseok | - |
dc.contributor.author | Zhao, Meng | - |
dc.contributor.author | Qiu ,Ji | - |
dc.contributor.author | Zhan, Xiaoming | - |
dc.contributor.author | Saxena, Ankur | - |
dc.contributor.author | Moore, Christopher J. | - |
dc.contributor.author | Cohen, Stanley N. | - |
dc.contributor.author | Georgiou, George | - |
dc.date.available | 2019-06-10T08:30:52Z | - |
dc.date.issued | 2006-07 | - |
dc.identifier.issn | 0950-382X | - |
dc.identifier.issn | 1365-2958 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/25565 | - |
dc.description.abstract | In Escherichia coli the initial step in the processing or decay of many messenger and structural RNAs is mediated by the endonuclease RNase E, which forms the core of a large RNA-catalysis machine termed the degradosome. Previous experiments have identified a protein that globally modulates RNA abundance by binding to RNase E and regulating its endonucleolytic activity. Here we report the discovery of RraB, which interacts with a different site on RNase E and interferes with cleavage of a different set of transcripts. We show that expression of RraA or RraB in vivo is accompanied by dramatic, distinct, and inhibitor-specific changes in degradosome composition - and that these are in turn associated with alterations in RNA decay and global transcript abundance profiles that are dissimilar to the profile observed during simple RNase E deficiency. Our results reveal the existence of endonuclease binding proteins that modulate the remodelling of degradosome composition in bacteria and argue that such degradosome remodelling is a mechanism for the differential regulation of RNA cleavages in E. coli. | - |
dc.format.extent | 13 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.title | Differential modulation of E. coli mRNA abundance by inhibitory proteins that alter the composition of the degradosome | - |
dc.type | Article | - |
dc.identifier.doi | 10.1111/j.1365-2958.2006.05246.x | - |
dc.identifier.bibliographicCitation | Molecular Microbiology, v.61, no.2, pp 394 - 406 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000238621900012 | - |
dc.identifier.scopusid | 2-s2.0-33748506522 | - |
dc.citation.endPage | 406 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 394 | - |
dc.citation.title | Molecular Microbiology | - |
dc.citation.volume | 61 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | binding protein | - |
dc.subject.keywordPlus | endonuclease | - |
dc.subject.keywordPlus | messenger RNA | - |
dc.subject.keywordPlus | ribonuclease | - |
dc.subject.keywordPlus | ribonuclease A | - |
dc.subject.keywordPlus | ribonuclease e | - |
dc.subject.keywordPlus | RNA | - |
dc.subject.keywordPlus | unclassified drug | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | catalysis | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | enzyme binding | - |
dc.subject.keywordPlus | enzyme deficiency | - |
dc.subject.keywordPlus | Escherichia coli | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | RNA structure | - |
dc.subject.keywordPlus | Endoribonucleases | - |
dc.subject.keywordPlus | Escherichia coli | - |
dc.subject.keywordPlus | Escherichia coli Proteins | - |
dc.subject.keywordPlus | Gene Expression Regulation, Bacterial | - |
dc.subject.keywordPlus | Multienzyme Complexes | - |
dc.subject.keywordPlus | Polyribonucleotide Nucleotidyltransferase | - |
dc.subject.keywordPlus | Protein Disulfide-Isomerase | - |
dc.subject.keywordPlus | Protein Interaction Mapping | - |
dc.subject.keywordPlus | Protein Structure, Tertiary | - |
dc.subject.keywordPlus | RNA Helicases | - |
dc.subject.keywordPlus | RNA Stability | - |
dc.subject.keywordPlus | RNA, Messenger | - |
dc.subject.keywordPlus | Surface Plasmon Resonance | - |
dc.subject.keywordPlus | Escherichia coli | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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