Regulation of gastric motility by ethanol is in part associated with cyclic nucleotide pathway
- Authors
- Sim, S.S.; Jo, Y.H.; Kim, M.S.; Kim, C.J.
- Issue Date
- 2000
- Keywords
- Cyclic AMP; Cyclic GMP; Ethanol; Smooth muscle relaxation
- Citation
- Asia Pacific Journal of Pharmacology, v.14, no.3, pp 73 - 78
- Pages
- 6
- Journal Title
- Asia Pacific Journal of Pharmacology
- Volume
- 14
- Number
- 3
- Start Page
- 73
- End Page
- 78
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/25588
- ISSN
- 0217-9687
- Abstract
- To investigate the underlying mechanism of ethanol in gastric smooth muscle relaxation, we examined the effect of ethanol on gastric motility and cyclic nucleotide pathway. Ethanol dose-dependently inhibited amplitude and frequency of spontaneous phasic contraction of cat gastric smooth muscle, whereas elicited tonic contraction at concentrations of more than 0.5%. Both spontaneous phasic contraction and 2% ethanol-induced tonic contraction were significantly inhibited by forskolin and sodium nitroprusside. Ethanol dose-dependently inhibited basal cyclic AMP levels and forskolin-induced cyclic AMP formation. On the other hand, ethanol significantly increased the basal cyclic GMP levels and sodium nitroprusside-induced cyclic GMP formation at low concentrations of less than 0.25%. However, ethanol at concentrations of more than 1% significantly inhibited sodium nitroprusside-induced cyclic GMP levels. These results suggest that regulation of gastric motility by ethanol is in part mediated via cyclic nucleotide pathway.
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