Fragility of Red Blood Cells Collected Under Different Conditions With a Cell Saver Device
- Authors
- Chung, Yoon Sang; Kim, Hye Ryoun; Kang, Hyun; Ryu, Choongun; Park, Byungjoon; Hong, Joonhwa
- Issue Date
- May-2019
- Publisher
- W B SAUNDERS CO-ELSEVIER INC
- Keywords
- operative blood cell salvage; blood cells; hemolysis; blood transfusion
- Citation
- JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, v.33, no.5, pp 1224 - 1229
- Pages
- 6
- Journal Title
- JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
- Volume
- 33
- Number
- 5
- Start Page
- 1224
- End Page
- 1229
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/25877
- DOI
- 10.1053/j.jvca.2018.11.019
- ISSN
- 1053-0770
1532-8422
- Abstract
- Objective: To quantify the degree of lethal and sublethal damage to red blood cells (RBCs) by cell saver (CS) processing among different conditions of shed blood in cardiac surgery. Design: Prospective randomized, double-blinded, controlled study. Setting: Single university hospital. Participants: Twenty rabbits were divided randomly into non-heparinized and heparinized groups. Thereafter, each group was subdivided into non-gauze and gauze groups based on whether the blood was collected with gauze and squeezed out. Interventions: Blood from each group was aspirated directly from the heart and underwent CS processing. Mechanical fragility index (MFI) and percent hemolysis were measured pre- and post-CS processing. Measurements and Main Results: In RBCs after CS processing, the MFI and percent hemolysis were increased significantly in both the non-heparinized and heparinized groups compared to pre-CS processing. The MFI was significantly higher in the heparinized group than in the non-heparinized group (p = 0.002). However, no differences in percent hemolysis were detected between groups (p = 0.696). The MFI and percent hemolysis of the non-gauze and gauze groups did not differ. Conclusion: This study reports the increase in sublethal and lethal injuries to RBCs from heparinized and non-heparinized blood after CS processing. CS-processed heparinized blood contained more sublethally injured RBCs compared to CS-processed non-heparinized blood. RBCs collected by squeezing blood-saturated gauze did not exhibit additional trauma. Further investigation is required to determine the clinical implications of transfusing rescued but injured RBCs using a CS. (C) 2018 Elsevier Inc. All rights reserved.
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