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Neuroprotective effect of Acanthopanax sessiliflorus against toxicity induced by N-methyl-D-aspartate in rat organotypic hippocampal slice cultureNeuroprotective Effect of Acanthopanax sessiliflorus against Toxicity Induced by N-Methyl-D-Aspartate in Rat Organotypic Hippocampal Slice Culture
- Authors
- Lee, P.; Lee, S.; Choi, S.Y.; Son, D.
- Issue Date
- Sep-2005
- Publisher
- 한국생약학회
- Keywords
- Acanthopanax sessiliflorus; Araliaceae; Exicitoxicity; Hippocampal slice culture; N-methyl-D-aspartate; Neuroprotection
- Citation
- Natural Product Sciences, v.11, no.3, pp 179 - 182
- Pages
- 4
- Journal Title
- Natural Product Sciences
- Volume
- 11
- Number
- 3
- Start Page
- 179
- End Page
- 182
- ISSN
- 1226-3907
- Abstract
- We investigated that water extract of Acanthopanax sessiliflorus roots rescued the N-methyl-D-aspartate (NMDA), agonist of glutamate receptor, -induced toxicity in rat organotypic hippocampal slice culture. When the cell death in NMDA only-treated hippocampal slices was set 100%, A. sessiliflorus decreased the cell death to 75.4, 51.6, 48.9, and 40.6% at 1, 10, 50, and 100 μg/ml treatment, respectively. On the basis of these results, the water extract of A. sessiliflorus roots may be a preventive agent against NMDA-induced cytotoxicity.
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Collections - College of Biotechnology & Natural Resource > ETC > 1. Journal Articles
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