Anti-inflammatory effect of germanium-concentrated yeast against paw oedema is related to the inhibition of arachidonic acid release and prostaglandin E2 production in RBL 2H3 cells
- Authors
- Lee, J.H.; Kim, K.W.; Yoon, M.Y.; Lee, J.Y.; Kim, C.J.; Sim, S.S.
- Issue Date
- Oct-2005
- Keywords
- Arachidonic acid; Germanium; Histamine; Inflammation
- Citation
- Autonomic and Autacoid Pharmacology, v.25, no.4, pp 129 - 134
- Pages
- 6
- Journal Title
- Autonomic and Autacoid Pharmacology
- Volume
- 25
- Number
- 4
- Start Page
- 129
- End Page
- 134
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/26141
- DOI
- 10.1111/j.1474-8673.2005.00335.x
- ISSN
- 1474-8665
- Abstract
- To investigate anti-inflammatory activity of organic germanium, we measured the effect of germanium-concentrated yeast on arachidonic acid release, prostaglandin E2 (PGE2) production, histamine release, and intracellular H2O2 or hydroperoxide generation in RBL 2H3 cells, and carrageenan-induced paw oedema in rats. Germanium-concentrated yeast dose-dependently inhibited carrageenan-induced paw oedema, suggesting that germanium-concentrated yeast has anti-inflammatory activity in acute inflammation. Germanium-concentrated yeast significantly inhibited melittin-induced arachidonic acid release and PGE2 production in RBL 2H3 cells. Germanium-concentrated yeast did not affect melittin-induced histamine release and silica-induced intracellular H2O2 or hydroperoxide generation in RBL 2H3 cells. These results suggest that anti-inflammatory activity of germanium-concentrated yeast appears partly to be related to the inhibition of arachidonic acid release and PGE2 production in RBL 2H3 cells. © 2005 Blackwell Publishing Ltd.
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