Anti-inflammatory Effect of Bear's Gall in Rat Microglia
- Authors
- Seong Soo Joo; Yeong Min Yoo; Seon Goo Lee; 이도익
- Issue Date
- 2005
- Publisher
- 한의병리학회
- Keywords
- microglia; bear's gall; Alzheimer's disease; IL-1β; Nitric Oxide
- Citation
- 동의생리병리학회지, v.19, no.1, pp 204 - 211
- Pages
- 8
- Journal Title
- 동의생리병리학회지
- Volume
- 19
- Number
- 1
- Start Page
- 204
- End Page
- 211
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/28271
- ISSN
- 1738-7698
2288-2529
- Abstract
- We hypothesize that bear's gall may have a certain role in anti-inflammation through a preventive effect of pro-inflammatory potentials. Secondly, we tried to connect the experimental results to Alzheimer's disease (AD), which chronic inflammation is a main cause of the disease. For this theme, we designed to elucidate the efficacy of bear's gall in suppressing the pro-inflammatory mediators, such as nitric oxide (NO) and interleukin-1β (IL-1β) in rat microglia. From the study, we concluded that bear's gall plays a positive role in suppressing such pro-inflammatory repertoire from rat microglia comparing to normal and positive control, such as culture media and cyclosporine. Interestingly, bear's gall showed a prolonged effect of anti-inflammation comparing with cyclosporine when time goes by up to 48h with a significant suppression at 1.2 ㎎/㎖. Therefore, we can consider that bear's gall in part can be applied to AD therapy in that it suppresses the expression of pro-inflammatory mediators as well as its continued effect.
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