자가연골세포와 PLA-coated PGA 복합체를 이용한 연골조직 재생Engineering Autogenous Cartilage Using PLA Coated PGA Chondrocyte Complex
- Authors
- 김우섭
- Issue Date
- 2005
- Publisher
- 대한성형외과학회
- Keywords
- Autogeous; Cartilge; Tissue engineering
- Citation
- Archives of Plastic Surgery, v.32, no.1, pp 1 - 4
- Pages
- 4
- Journal Title
- Archives of Plastic Surgery
- Volume
- 32
- Number
- 1
- Start Page
- 1
- End Page
- 4
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/28312
- ISSN
- 2234-6163
2234-6171
- Abstract
- Previous sucessful results of neocartilage formation using tissue engineering technique in immunocompromised nude mouse xenograft model were reported. For clinical application, autogenous cell is preferrable to allogenic or xenogenic cell for circumvention of immune rejection. This study evaluates the feasibility of producing a engineered cartilage using autogenous chondrocytes. Chondrocytes were isolated from the auricular catilage of New Zealand White rabbit and seeded onto PGA polymer coated with polylactic acid in round pattern(diameter 0.7 cm, thickness 0.1 cm) at a concentration 7 × 107 chondrocytes per cm3. Each Autogenous Cell-polymer constructs were implanted subcutaneously into the left side of dorsum of twelve Rabbits. Polymer templates not containg cells were implanted into the right side as a control. Fifteen rabbits were sacrificed at the following intervals: 5 rabbits at nine weeks, 7 rabbits at twelve weeksNew autogenous cartilage formation which retained the approximate dimensions of origianl round polymer template in 11 of 12 cell seeded implants. Histological examination using hematoxyline and eosin stain revealed vast majority of implants developed into mature cartilage. This study opens up the possibility of autologus cell transplant to construct autogenous cartilge.
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