BF-7의 기억력 및 인지기능 향상효과The Role of BF-7 on Enhancement of Memory and Cognitive Funtion
- Authors
- 김대경; 이준영; 성정준; 김의태; 김용식; 권오상; 윤영철; 이태진; 강용구; 정윤희; 김성수; 김경용; 이원복
- Issue Date
- Dec-2004
- Publisher
- 대한해부학회
- Keywords
- Memory; Cognitive function; BF-7; Scopolamine; Water maze; MMSE-K; 기억력; 인지기능
- Citation
- Anatomy and Cell Biology, v.37, no.6, pp 519 - 527
- Pages
- 9
- Journal Title
- Anatomy and Cell Biology
- Volume
- 37
- Number
- 6
- Start Page
- 519
- End Page
- 527
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/28411
- ISSN
- 2093-3665
2093-3673
- Abstract
- Various factors such as senescence, stress, neurodegenerative diseases including Alzheimer's disease (AD) contribute to the impairments of organs, especially brain. Also, they should be negative factors on normal brain function, like as memory and cognition. In this study, the neuroprotective role of BF-7, extracted from Bombyx mori, was examined agaist scopolamine-induced neurotoxicity in SK-N-SH cells. In order to know if the BF-7 has positive role on the cognition and memory, we examined using SD rat model and human. Scopolamine-induced memory impairments were observed, as measured by the passive avoidance and water maze tests, but treatment with BF-7 significantly improved memory and cognitive function. Moreover, the memory index and memory preservation of clinical experiments using MMSE-K tests were significantly improved memory and cognitive function. This results strongly represent that the BF-7 play effectively positive role in the improvement of brain function including learning and memory. Taken together, our results suggested that the BF-7 should be useful for developing strategies protecting nervous system and improving brain function.
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