Visible Light-Induced Aromatic Difluoroalkylation
- Authors
- Jung, Jaehun; Kim, Eunjin; You, Youngmin; Cho, Eun Jin
- Issue Date
- Sep-2014
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- aromatics; difluoroalkylation; heteroaromatics; iridium; visible light
- Citation
- ADVANCED SYNTHESIS & CATALYSIS, v.356, no.13, pp 2741 - 2748
- Pages
- 8
- Journal Title
- ADVANCED SYNTHESIS & CATALYSIS
- Volume
- 356
- Number
- 13
- Start Page
- 2741
- End Page
- 2748
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/28438
- DOI
- 10.1002/adsc.201400542
- ISSN
- 1615-4150
1615-4169
- Abstract
- Difluoroalkylated aromatics are important structural motifs in pharmaceutical and agrochemical applications. Herein, we report their synthesis by a mild, efficient, and convenient method using visible light photoredox catalysis. A variety of unactivated aromatics were difluoroalkylated with ethyl 2-bromo-2,2-difluoroacetate (BrCF2CO2Et) in the presence of the triscyclometalated Ir complex fac-[Ir(ppy)(3)] under visible light irradiation at room temperature. It is shown that reaction outcomes containing the CF2CO2Et moiety can be converted to a variety of other CF2-containing aromatics, demonstrating the synthetic utility of the present method.
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Collections - College of Natural Sciences > Department of Chemistry > 1. Journal Articles
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