Synthesis of 1,3,5-trisubstituted-1,2,4-triazoles by microwave-assisted N-acylation of amide derivatives and the consecutive reaction with hydrazine hydrochlorides
- Authors
- Lee, Jongbok; Hong, Myengchan; Jung, Yoonchul; Cho, Eun Jin; Rhee, Hakjune
- Issue Date
- Feb-2012
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Microwave-assisted reaction; 1,2,4-Triazole; N-Acylation reaction; Cyclization reaction; One-pot sequential reaction
- Citation
- TETRAHEDRON, v.68, no.8, pp 2045 - 2051
- Pages
- 7
- Journal Title
- TETRAHEDRON
- Volume
- 68
- Number
- 8
- Start Page
- 2045
- End Page
- 2051
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/28452
- DOI
- 10.1016/j.tet.2012.01.003
- ISSN
- 0040-4020
- Abstract
- Facile and efficient procedures for the N-acylation reaction of amide derivatives with various acid anhydrides and the cyclization reaction of N-acylated amide derivatives with various hydrazine hydrochlorides were described. The reactions were carried out under microwave irradiation to give products in good yields in a few minutes. The synthesis of 1,3,5-trisubstituted-1,2,4-triazoles from benzamides can also be accomplished in a simple one-pot sequential reaction. (C) 2012 Elsevier Ltd. All rights reserved.
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Collections - College of Natural Sciences > Department of Chemistry > 1. Journal Articles
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