정신분열병 환자의 혈청에서 Brain-Derived Neurotrophic Factor 증가Serum Brain-Derived Neurotrophic Factor in Schizophrenia
- Authors
- 김소연; 민경준; 기백석; 박두병; 김주희
- Issue Date
- 2004
- Publisher
- 대한생물정신의학회
- Keywords
- BDNF; Schizophrenia; Neurotrophin; 정신분열병; 신경조절인자
- Citation
- 생물정신의학, v.11, no.2, pp 104 - 109
- Pages
- 6
- Journal Title
- 생물정신의학
- Volume
- 11
- Number
- 2
- Start Page
- 104
- End Page
- 109
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/28481
- ISSN
- 1225-8709
- Abstract
- Abnormalities in neurotrophic factors that regulate neuronal development and synaptic plasticity
are often implicated as some causes of schizophrenia. In previous studies, researchers reported that brain
and serum BDNF levels underwent similar changes during maturation and aging processes in rats. They
also found a positive correlation between serum and cortical BDNF levels. In this study, we investigated whether
the serum levels of BDNF in Korean schizophrenic patients would be different from those of healthy controls.
Methods:Using an ELISA kit, serum BDNF levels were assessed in schizophrenic group(N=49) and control
group(N=50).
Results:Serum BDNF levels in the schizophrenic group(36.29±19.78ng/ml) were significantly higher than
those in control group(22.4±14.4ng/ml). The BDNF levels did not correlate with duration of treatment, age or
daily dose of antipsychotics in patients with schizophrenia.
Conclusions:This result suggests that schizophrenia is characterized by high serum BDNF levels and supports
the hypothesis of neurotrophic factor involvement in psychotic disorder. Serum BDNF level is likely to be one
of the possible biological markers for schizophrenia.
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