친수성 폴리머 제피를 이용한 말레인산암로디핀 정제의 안정성 개선Stability Improvement of Amlodipine Maleate Tablets using Aqueous Polymer Coating Technique
- Authors
- 최영욱; 최인식; 신택환; 최성업; 이재휘
- Issue Date
- 2004
- Publisher
- 한국약제학회
- Keywords
- Amlodipine maleate; Stability; Aqueous polymer coating; Opadry
- Citation
- Journal of Pharmaceutical Investigation, v.34, no.5, pp 407 - 411
- Pages
- 5
- Journal Title
- Journal of Pharmaceutical Investigation
- Volume
- 34
- Number
- 5
- Start Page
- 407
- End Page
- 411
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/28521
- ISSN
- 2093-5552
2093-6214
- Abstract
- New formulations of amlodipine maleate tablet have been investigated to enhance the stability of the drug against light and humidity. Three kinds of amlodipine maleate tablets were prepared. One is prepared by previously known formulation (formulation C), the others were by new formulations using hydrophilic polymer (Opadry) coated granules (formulations A and B). Amlodipine maleate powder was coated with Opadry to produce the coated granules and it was mixed with other excipients to produce the tabletting mass of new formulations A and B. Dissolution rate of newly formulated tablets was over 80% within 10 minutes in 0.01M HCl medium, and its dissolution pattern was similar to that of Norvasc tablet. After 6 months storage under accelerated conditions, residual drug contents of tested formulations (A and B) were not significantly different from formulation C, ranging from 96.2 to 100.4%. Meanwhile, dissolution amount of formulation C was significantly reduced compared to that of formulation A (p<0.05), showing formulation A was more stable than unprotected formulation C at the accelerated conditions. Results of appearance, hardness and disintegration remained unchanged during stability study. In conclusion, it showed that the new formulations had enhanced the stability characteristics and hydrophilic coating technique was an alternative and promising method to improve the stability of amlodipine maleate tablet.
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Collections - Graduate School > ETC > 1. Journal Articles
- College of Pharmacy > School of Pharmacy > 1. Journal Articles
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