β-아드레날린성 수용체 아형에 대한 효현제 및 길항제가 토끼 정낭의 수축 및 이완 반응에 미치는 영향
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 명순철 | - |
dc.contributor.author | 금은미 | - |
dc.contributor.author | 곽경원 | - |
dc.contributor.author | 이무열 | - |
dc.contributor.author | 김세철 | - |
dc.date.available | 2019-07-16T05:04:08Z | - |
dc.date.issued | 2004-07 | - |
dc.identifier.issn | 0494-4747 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/28645 | - |
dc.description.abstract | Purpose: This study was aimed at investigating the role of β-adrenoceptor subtypes in mediating the relaxation and contraction of seminal vesicles in rabbits. Materials and Methods: Relaxation or contractile responses of epithelium- removed muscle strips of a rabbit seminal vesicle, which were precontracted with 10-5M norepinephrine, to selective β subtypes-adrenoceptor agonists were observed in an organ bath. The contractile responses induced by isoproterenol were also observed after application of selective antagonists. Results: Isoproterenol showed a concentration-dependent contractile response, but the contractility was weaker than those with phenylephrine and norepinephrine. The β selective-agonists(xamoterol for β1, clenbuterol for β2 and BRL37344 for β3) alone evoked neither contraction nor relaxation. However, the β1- and β3-agonists inhibited the contraction of the precontracted strips with 10-5M norepinephrine, while the β2-agonist enhanced the contraction. The pretreatment with a β2-antagonist(ICI118551) reduced the tension of the strips developed by 10-4M isoproterenol, but the β1-(atenolol) and β3-(SR59230A) antagonists showed no changes in the response. Conclusions: β1- and β3-adrenoceptors seem to mediate the relaxation of the seminal vesicle, while the β2-adrenoceptor may have a supplementary role in contraction. (Korean J Urol 2004;45:726-731) | - |
dc.format.extent | 6 | - |
dc.publisher | 대한비뇨기과학회 | - |
dc.title | β-아드레날린성 수용체 아형에 대한 효현제 및 길항제가 토끼 정낭의 수축 및 이완 반응에 미치는 영향 | - |
dc.title.alternative | Contraction and Relaxation Responses of Isolated Rabbit Seminal Vesicle to Selective β Subtypes-adrenoceptor Agonists and Antagonists | - |
dc.type | Article | - |
dc.identifier.bibliographicCitation | 대한비뇨기과학회지, v.45, no.7, pp 726 - 731 | - |
dc.identifier.kciid | ART001105248 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 731 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 726 | - |
dc.citation.title | 대한비뇨기과학회지 | - |
dc.citation.volume | 45 | - |
dc.identifier.url | http://urology.inforang.com/journal/main.html?mod=vol | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Seminal vesicle | - |
dc.subject.keywordAuthor | Beta-adrenoceptor | - |
dc.subject.keywordAuthor | Contraction | - |
dc.subject.keywordAuthor | Relaxation | - |
dc.description.journalRegisteredClass | kci | - |
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