β-아드레날린성 수용체 아형에 대한 효현제 및 길항제가 토끼 정낭의 수축 및 이완 반응에 미치는 영향Contraction and Relaxation Responses of Isolated Rabbit Seminal Vesicle to Selective β Subtypes-adrenoceptor Agonists and Antagonists
- Authors
- 명순철; 금은미; 곽경원; 이무열; 김세철
- Issue Date
- Jul-2004
- Publisher
- 대한비뇨기과학회
- Keywords
- Seminal vesicle; Beta-adrenoceptor; Contraction; Relaxation
- Citation
- 대한비뇨기과학회지, v.45, no.7, pp 726 - 731
- Pages
- 6
- Journal Title
- 대한비뇨기과학회지
- Volume
- 45
- Number
- 7
- Start Page
- 726
- End Page
- 731
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/28645
- ISSN
- 0494-4747
- Abstract
- Purpose: This study was aimed at investigating the role of β-adrenoceptor subtypes in mediating the relaxation and contraction of seminal vesicles in rabbits.
Materials and Methods: Relaxation or contractile responses of epithelium- removed muscle strips of a rabbit seminal vesicle, which were precontracted with 10-5M norepinephrine, to selective β subtypes-adrenoceptor agonists were observed in an organ bath. The contractile responses induced by isoproterenol were also observed after application of selective antagonists.
Results: Isoproterenol showed a concentration-dependent contractile response, but the contractility was weaker than those with phenylephrine and norepinephrine. The β selective-agonists(xamoterol for β1, clenbuterol for β2 and BRL37344 for β3) alone evoked neither contraction nor relaxation. However, the β1- and β3-agonists inhibited the contraction of the precontracted strips with 10-5M norepinephrine, while the β2-agonist enhanced the contraction. The pretreatment with a β2-antagonist(ICI118551) reduced the tension of the strips developed by 10-4M isoproterenol, but the β1-(atenolol) and β3-(SR59230A) antagonists showed no changes in the response.
Conclusions: β1- and β3-adrenoceptors seem to mediate the relaxation of the seminal vesicle, while the β2-adrenoceptor may have a supplementary role in contraction. (Korean J Urol 2004;45:726-731)
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