황금 지상부의 항산화 및 항 알러지 활성 성분

Abstract

of Scutellaria baicalensis have been used for fever remedy, diuresis, antiphlogistic. For the investigationof the active component from aerial parts of Scutellaria baicalensis, MeOH extracts from aerial parts of Scutellaria baicalensiswere suspended with H2O, and partitioned by CHCl3. In order to investigate the efficacy of antioxidative activity, the activityguided fraction and isolation of physiologically active substance were performed. Its H2O, 30%, 60% MeOH and MeOH frac-MeOH fractions have significant anti-oxidative activity. its fractions testing type I allergy, compound 48/80 induced systemicanaphylaxis was applied. As a result, compared with reference (cromolygate), these fraction significantly inhibited systemicanaphylaxis by 71% and 57%, respectively. From 30%, 60% MeOH fraction, five compounds were isolated and elucidatedapigenin 6-C-α-L-arabinopyranosyl-8-C-β-D-glucopyranoside (isoschaftside, I), scutellarein 7-O-β-D-glucuronopyranoside(scutellarin, II), apigenin 7-O-β-D-glucuronopyranoside (III), isoscutellarein 8-O-β-D-glucuronopyranoside (IV), kaempferol3-O-βenging activity with DPPH method and anti-lipid peroxidative efficacy on human LDL with TBARS assay. [I<IV. V. III<