RBL 2H3 비만세포에서 히스타민 유리와 칼슘과의 관계Relationship Between Histamine Release and Ca Mobilizaton in RBL 2H3 Mast Cells
- Authors
- 박성훈; 김수정; 김정민; 박주현; 최방실; 이지윤; 최미영; 심상수
- Issue Date
- 2007
- Publisher
- 대한약학회
- Keywords
- mast cells; histamine; calcium; calmodulin antagonist
- Citation
- 약 학 회 지, v.51, no.1, pp 63 - 67
- Pages
- 5
- Journal Title
- 약 학 회 지
- Volume
- 51
- Number
- 1
- Start Page
- 63
- End Page
- 67
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/30242
- ISSN
- 0377-9556
- Abstract
- To investigate the relation between extracellular Ca2+ and histamine release, we observed agonist-induced his-tamine release from RBL 2H3 mast cells in the presence or absence of extracellular Ca2+ concentration. Histamine releaseinduced by melittin and thapsigargin were greater in the presence of extracellular Ca2+ than in the absence of extracellularCa2+ . Econazole-induced histamine release had nothing to do with extracellular Ca2+ , whereas arachidonic acid-induced his-2+ . Calmodulin antagonists did not affect melittin-induced his-tamine release but they may potentiate arachidonic acid-induced histamine release. These data suggest that arachidonicacid-induced histamine release may be mediated via Ca2+ -independent pathway and may be potentiated by the block ofCa2+ -dependent pathway.Keywords . mast cells, histamine, calcium, calmodulin antagonist..... ....... histamine. ... ... Ca2+
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Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
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