바위취 에탄올 추출물의 항산화 및 항노화 작용Anti-oxidant and Anti-aging Activity on Saxifraga stolonifera MEERBURGH Ethanol Extract
- Authors
- 윤미연; 임혜원; 심상수; 최태부
- Issue Date
- 2007
- Publisher
- 대한약학회
- Keywords
- Saxifraga stolonifera; ROS; collagen; anti-aging
- Citation
- 약 학 회 지, v.51, no.4, pp 343 - 349
- Pages
- 7
- Journal Title
- 약 학 회 지
- Volume
- 51
- Number
- 4
- Start Page
- 343
- End Page
- 349
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/30517
- ISSN
- 0377-9556
- Abstract
- To investigate the effect of ethanol extract of Saxifraga stolonifera MEERBURGH on skin care, we measured
anti-oxidant and anti-aging activity. S. stolonifera ethanol extract itself had anti-oxidant activity in a dose-dependent manner
in DPPH radical scavenging. Silica dose-dependently increased the intracellular ROS generation in RAW 264.7 cells. S.
stolonifera ethanol extract inhibited silica-induced intracellular superoxide anion generation, H2O2 and hydroperoxide generation
in RAW 264.7 cells. S. stolonifera ethanol extract significantly inhibited both hyaluronidase and elastase activity, also
significantly inhibited MMP-1(collagenase) activity as well. In NIH 3T3 fibroblast cells, S. stolonifera ethanol extract significantly
increased collagen-like polymer synthesis, which suggesting the S. stolonifera ethanol extract might be used as
hydration and anti-wrinkle agents. From the above results, it is suggested that the main ingredients of S. stolonifera ethanol
extract play an important role in anti-oxidant and anti-aging activity.
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