β-Lactamase 억제작용이 기대되는 7-Arylidene Cephalosporanate 유도체의 합성Synthesis of 7-Arylidene Cephalosporanates for β-Lactamase Inhibitor
- Authors
- 이종민; 임철부; 임채욱
- Issue Date
- 2008
- Publisher
- 대한약학회
- Keywords
- 7-arylidene cephalosporanates; β-lactamase inhibitors
- Citation
- 약 학 회 지, v.52, no.4, pp 311 - 315
- Pages
- 5
- Journal Title
- 약 학 회 지
- Volume
- 52
- Number
- 4
- Start Page
- 311
- End Page
- 315
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/31268
- ISSN
- 0377-9556
- Abstract
- The synthesis of 7-arylidene cephalosporanates for β-lactamase inhibitor was described. The reactions of substituted benzyl halides [1]~[3] with triphenylphosphine gave triphenylphosphonium chlorides [4]~[6]. These phosphonium salts were treated with n-butyllithium to give ylides, which were reated with 7-oxocephalosporanate [7] by Wittig reaction to afford the 7-exomethylene cephalosporanates [8]~[10]. These cephalosporanates were oxidized to cephalosporanate sulfones [11]~[13] with mCPBA. The deprotection of benzhydryl cephalosporanate [8]~[13] with AlCl3 and NaHCO3 gave sodium salts of 7-arylidene cephalosporanates [14]~[19].
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Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
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