정상 간기능을 보이는 발프로산 유발 고암모니아혈증성 뇌병증 1예A case of valproic acid-induced hyperammonemic encephalopathy with normal liver function
- Authors
- 최종학; 김정은; 이광선; 허채; 남택균; 김정욱; 박승원
- Issue Date
- 2008
- Publisher
- 대한내과학회
- Keywords
- 밸프로산; 고암모니아혈증; 부작용; 경련; Valproic acid; Hyperammonemia; Adverse effect; Seizure
- Citation
- 대한내과학회지, v.75, no.6, pp 680 - 684
- Pages
- 5
- Journal Title
- 대한내과학회지
- Volume
- 75
- Number
- 6
- Start Page
- 680
- End Page
- 684
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/31744
- ISSN
- 1738-9364
2289-0769
- Abstract
- Valproic acid is an effective anticonvulsant used in neurology and psychiatry. Valproic acid-induced hyperammonemic encephalopathy is an unusual complication characterized by a decreasing level of consciousness, the development of progressive confusional states and, sometimes, a coexisting increase in the frequency of seizures after the onset of valproic acid treatment. It can lead to death, but can be reversed if a swift diagnosis is made. We report the case of a 58-year-old woman with an intracerebral hemorrhage and normal liver function who presented with valproic acid-induced hyperammonemic encephalopathy. After valproic acid treatment, she developed encephalopathy and became comatose, with seizures and a markedly elevated serum ammonia level. Her neurologic manifestations and hyperammonemia improved after discontinuing the valproic acid. (Korean J Med 75:680-684, 2008)
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