Serum Concentration of Estradiol and Estrone Following Oral Administration of Low-dose Hormone Therapy in Postmenopausal Korean Women
DC Field | Value | Language |
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dc.contributor.author | 이은주 | - |
dc.contributor.author | Byung Seok Lee | - |
dc.contributor.author | Byung-Moon Kang | - |
dc.contributor.author | Byung-Koo Yoon | - |
dc.contributor.author | Hoon Choi | - |
dc.contributor.author | Jung Gu Kim | - |
dc.contributor.author | 박형무 | - |
dc.date.available | 2019-08-07T01:55:30Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 2288-6478 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/31790 | - |
dc.description.abstract | Objectives: To determine the baseline serum concentrations of estradiol and estrone in postmenopausal Korean women and the serum concentrations of estradiol and estrone after 4 and 16 weeks of treatment using 1 mg of estradiol and 2 mg of drospirenone. Methods: This was a multicenter study. Thirty-six subjects were screened. Serum estradiol, estrone and drospirenone levels were determined by gas chromatography-mass spectrometry and radioimmunoassay. Results: The mean estradiol concentration was 8.37 ± 12.1 pg/mL at baseline and increased to 53.7 ± 52.1 and 41.4 ± 26.1 pg/mL after 4 and 16 weeks of treatment, respectively. The mean estrone concentrations were 28.7 ± 26.8, 266.1 ± 182.9, and 256.1 ± 179.1 pg/mL at baseline, and after 4 and 16 weeks of treatment, respectively. When women were stratified according to the basal estradiol level, the level after 4 weeks of treatment was significantly higher in the women with a detectable level (≥ 5 pg/mL) than in women with an undetectable level (< 5 pg/mL; 65.2 ± 21.5 vs. 37.4 ± 25.8 pg/mL, P = 0.008). After 16 weeks of treatment, the estradiol level was still higher in the detectable group (51.6 ± 28.6 vs. 38.7 ± 21.7 pg/mL, P = 0.09). Conclusion: This study showed that 1 mg of estradiol and 2 mg of drospirenone is an appropriate regimen to achieve the desired serum estradiol level. The difference in serum hormonal levels after 4 weeks of treatment could be caused by different basal levels. | - |
dc.format.extent | 6 | - |
dc.publisher | 대한폐경학회 | - |
dc.title | Serum Concentration of Estradiol and Estrone Following Oral Administration of Low-dose Hormone Therapy in Postmenopausal Korean Women | - |
dc.type | Article | - |
dc.identifier.bibliographicCitation | 대한폐경학회지, v.17, no.2, pp 75 - 80 | - |
dc.identifier.kciid | ART001675762 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 80 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 75 | - |
dc.citation.title | 대한폐경학회지 | - |
dc.citation.volume | 17 | - |
dc.subject.keywordAuthor | Drospirenone | - |
dc.subject.keywordAuthor | Estradiol | - |
dc.subject.keywordAuthor | Estrogen replacement therapy | - |
dc.subject.keywordAuthor | Estrone | - |
dc.subject.keywordAuthor | Postmenopause | - |
dc.description.journalRegisteredClass | kciCandi | - |
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