Serum Concentration of Estradiol and Estrone Following Oral Administration of Low-dose Hormone Therapy in Postmenopausal Korean Women
- Authors
- 이은주; Byung Seok Lee; Byung-Moon Kang; Byung-Koo Yoon; Hoon Choi; Jung Gu Kim; 박형무
- Issue Date
- 2011
- Publisher
- 대한폐경학회
- Keywords
- Drospirenone; Estradiol; Estrogen replacement therapy; Estrone; Postmenopause
- Citation
- 대한폐경학회지, v.17, no.2, pp 75 - 80
- Pages
- 6
- Journal Title
- 대한폐경학회지
- Volume
- 17
- Number
- 2
- Start Page
- 75
- End Page
- 80
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/31790
- ISSN
- 2288-6478
- Abstract
- Objectives: To determine the baseline serum concentrations of estradiol and estrone in postmenopausal Korean women and the serum concentrations of estradiol and estrone after 4 and 16 weeks of treatment using 1 mg of estradiol and 2 mg of drospirenone.
Methods: This was a multicenter study. Thirty-six subjects were screened. Serum estradiol, estrone and drospirenone levels were determined by gas chromatography-mass spectrometry and radioimmunoassay.
Results: The mean estradiol concentration was 8.37 ± 12.1 pg/mL at baseline and increased to 53.7 ± 52.1 and 41.4 ± 26.1 pg/mL after 4 and 16 weeks of treatment, respectively. The mean estrone concentrations were 28.7 ± 26.8, 266.1 ± 182.9, and 256.1 ± 179.1 pg/mL at baseline, and after 4 and 16 weeks of treatment, respectively. When women were stratified according to the basal estradiol level, the level after 4 weeks of treatment was significantly higher in the women with a detectable level (≥ 5 pg/mL) than in women with an undetectable level (< 5 pg/mL; 65.2 ± 21.5 vs. 37.4 ± 25.8 pg/mL, P = 0.008). After 16 weeks of treatment, the estradiol level was still higher in the detectable group (51.6 ± 28.6 vs. 38.7 ± 21.7 pg/mL, P = 0.09).
Conclusion: This study showed that 1 mg of estradiol and 2 mg of drospirenone is an appropriate regimen to achieve the desired serum estradiol level. The difference in serum hormonal levels after 4 weeks of treatment could be caused by different basal levels.
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