실리마린의 용출개선 및 흰쥐에서의 생체이용률 평가Improved Dissolution Characteristics of Silymarin and Their Bioavailability in Rats
- Authors
- 김정훈; 장선우; 권종원; 김원배; 최영욱
- Issue Date
- 2003
- Publisher
- 한국약제학회
- Citation
- Journal of Pharmaceutical Investigation, v.33, no.1, pp 10 - 65
- Pages
- 56
- Journal Title
- Journal of Pharmaceutical Investigation
- Volume
- 33
- Number
- 1
- Start Page
- 10
- End Page
- 65
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/32271
- ISSN
- 2093-5552
2093-6214
- Abstract
- Silybin is the main component of Cardus marianus extracts originated from Silybum marianum and has a hepato-protective effect. It is a water-insoluble compound and poorly absorbed from the gastrointestinal tract, resulting in very low oral bioavailability(BA). Polymeric mixed-micelle precursor formulation was made to enhance the dissolution rate of silybin, showing the results of pH-independent release profile with increased dissolution. Oral BA of different preparations in rats was evaluated, revealing that the new formulation showed increased BA more than 2-fold and 4-fold compared to the marketed product and Cardus marianus extracts itself, respectively.
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Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
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