B16 Melanoma세포에서 Citrus Essential Oil 이 Melanin 생성에 미치는 영향Effects of Citrus Essential Oils on Melanin Production in B16 Melanoma Cells
- Authors
- 임혜원; 조남영; 윤미연; 차상복; 김경원; 박영미; 이지윤; 이진희; 김창종; 심상수
- Issue Date
- 2003
- Publisher
- 대한약학회
- Citation
- 약 학 회 지, v.47, no.1, pp 25 - 30
- Pages
- 6
- Journal Title
- 약 학 회 지
- Volume
- 47
- Number
- 1
- Start Page
- 25
- End Page
- 30
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/32305
- ISSN
- 0377-9556
- Abstract
- This study is performed to investigate the effects of citrus essential oils on melanin production in B16 melanoma cells. Five kinds of citrus essential oils (Bergamot, Grapefruit, Lemon, Mandarin, Petigrain) did not have any influence on DPPH radical scavenger activity, cell growth and cytotoxicity in B16 melanoma cells. Both mandarin and petigrain essential oils dose-dependently inhibited purified tyrosinase activity, but bergamot did not. In 1μM MSH-stimulated B16 melanoma cells, all of 5 citrus essential oils inhibited melanin production in a dose dependent manner. From the above results, it is possible that citrus essential oils may be developed to be an anti-melanogenesis agent on the basis of their inhibitory effect on MSH-induced melanin production.
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Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
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