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Potent anti-adhesion agent using a drug-eluting visible-light curable hyaluronic acid derivative
- Authors
- Han, Ga-Dug; Kim, Jae-Won; Noh, Seung-Hyun; Kim, Shin-Woong; Jang, Eui-Chan; Nah, Jae-Woon; Lee, Young-Gi; Kim, Mi-Kyung; Ito, Yoshihiro; Son, Tae-Il
- Issue Date
- Feb-2019
- Publisher
- Korean Society of Industrial Engineering Chemistry
- Keywords
- Furfuryl hyaluronic acid; Ibuprofen; Photo-immobilization; Riboflavin; Anti-adhesion; Anti-inflammation
- Citation
- Journal of Industrial and Engineering Chemistry, v.70, pp 204 - 210
- Pages
- 7
- Journal Title
- Journal of Industrial and Engineering Chemistry
- Volume
- 70
- Start Page
- 204
- End Page
- 210
- ISSN
- 1226-086X
1876-794X
- Abstract
- Post-operative adhesion is a very serious complication in the clinical field, frequently occurring after surgery. In severe cases, reoperation may be required. In this study, a visible light-curable furfuryl hyaluronic acid derivative was prepared and combined with ibuprofen for anti-adhesion and anti-inflammatory applications. A furfuryl isocyanate moiety was introduced in hyaluronic acid affording furfuryl hyaluronic acid (F-HA). The anti-adhesion and anti-inflammatory effects of F-HA were examined in chickens at 2, 4, and 8 weeks postoperation. It was concluded that F-HA combined with ibuprofen is a suitable anti-adhesion and anti-inflammation agent. © 2018 The Korean Society of Industrial and Engineering Chemistry
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