알코올 및 H2O2 유도 신경세포 사멸에 대항하여 참취와 초석잠 함유 빵의 뇌신경세포 보호 효과
DC Field | Value | Language |
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dc.contributor.author | Kim, S.J. | - |
dc.contributor.author | Lee, S. | - |
dc.contributor.author | Park, S.E. | - |
dc.contributor.author | Lee, J.S. | - |
dc.contributor.author | Chung, M.J. | - |
dc.date.available | 2019-03-08T06:56:34Z | - |
dc.date.issued | 2018-01 | - |
dc.identifier.issn | 1226-3311 | - |
dc.identifier.issn | 2288-5978 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/3273 | - |
dc.description.abstract | The present study evaluated the neuroprotective effects of Aster scaber Thunb. (AS), Stachys sieboldii Miq. (SS), and their mixture at a ratio of 1:1 (ASM) based on antioxidant activity. The 70% ethanol extracts of AS, SS, and ASM (ASE, SSE, and AS-M, respectively) scavenged DPPH radical in a dose-dependent manner and strongly suppressed cellular reactive oxygen species, thereby protecting against H2O2- or ethanol-induced cytotoxicity in human brain neuroblastoma SK-N-SH cells. AS-M showed higher antioxidant activity and neuroprotective effects than ASE and SSE. In a continuing study, the neuroprotective effects of extract of bread containing AS, SS, and ASM (ASB, SSB, and AS-MB, respectively) against H2O2- or ethanol-induced cytotoxicity in SK-N-SH cells were investigated. Treatment with ASB, SSB, and AS-MB reduced cytotoxicity of H2O2 or ethanol in SK-N-SH cells and reduced the intracellular reactive oxygen species level. Treatment with main compounds (astragalin and isoquercitrin) isolated from Aster scaber Thunb. showed protective effects against ethanol-induced cell death by up-regulation of the HO-1 antioxidant gene. © 2018, Korean Society of Food Science and Nutrition. All rights reserved. | - |
dc.format.extent | 8 | - |
dc.language | 한국어 | - |
dc.language.iso | KOR | - |
dc.publisher | Korean Society of Food Science and Nutrition | - |
dc.title | 알코올 및 H2O2 유도 신경세포 사멸에 대항하여 참취와 초석잠 함유 빵의 뇌신경세포 보호 효과 | - |
dc.title.alternative | Neuroprotective effects of bread containing aster scaber thunb. and Stachys Sieboldii Miq. against ethanol- or H2O2-induced neuronal cell death | - |
dc.type | Article | - |
dc.identifier.doi | 10.3746/jkfn.2018.47.1.024 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Society of Food Science and Nutrition, v.47, no.1, pp 24 - 31 | - |
dc.identifier.kciid | ART002312713 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85041395961 | - |
dc.citation.endPage | 31 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 24 | - |
dc.citation.title | Journal of the Korean Society of Food Science and Nutrition | - |
dc.citation.volume | 47 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Antioxidant activity | - |
dc.subject.keywordAuthor | Aster scaber thunb. | - |
dc.subject.keywordAuthor | Cytotoxicity | - |
dc.subject.keywordAuthor | Neuroprotective effects | - |
dc.subject.keywordAuthor | Stachys sieboldii miq | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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