알코올 및 H2O2 유도 신경세포 사멸에 대항하여 참취와 초석잠 함유 빵의 뇌신경세포 보호 효과Neuroprotective effects of bread containing aster scaber thunb. and Stachys Sieboldii Miq. against ethanol- or H2O2-induced neuronal cell death
- Authors
- Kim, S.J.; Lee, S.; Park, S.E.; Lee, J.S.; Chung, M.J.
- Issue Date
- Jan-2018
- Publisher
- Korean Society of Food Science and Nutrition
- Keywords
- Antioxidant activity; Aster scaber thunb.; Cytotoxicity; Neuroprotective effects; Stachys sieboldii miq
- Citation
- Journal of the Korean Society of Food Science and Nutrition, v.47, no.1, pp 24 - 31
- Pages
- 8
- Journal Title
- Journal of the Korean Society of Food Science and Nutrition
- Volume
- 47
- Number
- 1
- Start Page
- 24
- End Page
- 31
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/3273
- DOI
- 10.3746/jkfn.2018.47.1.024
- ISSN
- 1226-3311
2288-5978
- Abstract
- The present study evaluated the neuroprotective effects of Aster scaber Thunb. (AS), Stachys sieboldii Miq. (SS), and their mixture at a ratio of 1:1 (ASM) based on antioxidant activity. The 70% ethanol extracts of AS, SS, and ASM (ASE, SSE, and AS-M, respectively) scavenged DPPH radical in a dose-dependent manner and strongly suppressed cellular reactive oxygen species, thereby protecting against H2O2- or ethanol-induced cytotoxicity in human brain neuroblastoma SK-N-SH cells. AS-M showed higher antioxidant activity and neuroprotective effects than ASE and SSE. In a continuing study, the neuroprotective effects of extract of bread containing AS, SS, and ASM (ASB, SSB, and AS-MB, respectively) against H2O2- or ethanol-induced cytotoxicity in SK-N-SH cells were investigated. Treatment with ASB, SSB, and AS-MB reduced cytotoxicity of H2O2 or ethanol in SK-N-SH cells and reduced the intracellular reactive oxygen species level. Treatment with main compounds (astragalin and isoquercitrin) isolated from Aster scaber Thunb. showed protective effects against ethanol-induced cell death by up-regulation of the HO-1 antioxidant gene. © 2018, Korean Society of Food Science and Nutrition. All rights reserved.
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