Biodegradable polymers for modern vaccine development
- Authors
- Bose, Rajendran J. C.; Kim, Minwoo; Chang, Ji Hyun; Paulmurugan, Ramasamy; Moon, James J.; Koh, Won-Gun; Lee, Soo-Hong; Park, Hansoo
- Issue Date
- Sep-2019
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- Biodegradable polymer; Adjuvant; Vaccine delivery system; Biomaterial; Biocompatibility
- Citation
- JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.77, pp 12 - 24
- Pages
- 13
- Journal Title
- JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
- Volume
- 77
- Start Page
- 12
- End Page
- 24
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/32831
- DOI
- 10.1016/j.jiec.2019.04.044
- ISSN
- 1226-086X
1876-794X
- Abstract
- Most traditional vaccines are composed either of a whole pathogen or its parts; these vaccines, however, are not always effective and can even be harmful, As such, additional agents known as adjuvants are necessary to increase vaccine safety and efficacy. This review summarizes the potential of biodegradable materials, including synthetic and natural polymers, for vaccine delivery. These materials are highly biocompatible and have minimal toxicity, and most biomaterial-based vaccines delivering antigens or adjuvants have been shown to improve immune response, compared to formulations consisting of the antigen alone. Therefore, these materials can be applied in modern vaccine development. (C) 2019 Published by Elsevier B.V. on behalf of The Korean Society of Industrial and Engineering Chemistry.
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