Incidence and mortality of osteoporotic fracture in rheumatoid arthritis in South Korea using nationwide claims data
- Authors
- Kwon, H.-Y.; Kim, H.-H.; Sung, Y.-K.; Ha, Y.-C.
- Issue Date
- 1-May-2019
- Publisher
- Korean Society for Bone and Mineral Research
- Keywords
- Arthritis, rheumatoid; Incidence; Mortality; Osteoporotic fractures
- Citation
- Journal of Bone Metabolism, v.26, no.2, pp 97 - 104
- Pages
- 8
- Journal Title
- Journal of Bone Metabolism
- Volume
- 26
- Number
- 2
- Start Page
- 97
- End Page
- 104
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/33189
- DOI
- 10.11005/jbm.2019.26.2.97
- ISSN
- 2287-6375
2287-7029
- Abstract
- Background: To investigate incidence and mortaltiy of osteoporotic fractures (including hip, spine, distal radius, and proximal humerus) in rheumatoid arthritis (RA) patients and compare them with those in the genearal population. Methods: Data provided by National Health Insurance Service were used to identify osteoporotic fractures in patients aged >50 years between 2010 and 2012. Patients with RA were identified by the diagnostic code for seropositive RA. Standardized mortality ratios (SMRs; observed/expected deaths) of osteoporotic fractures were calculated based on age and gender-specific rates in the entire Korean population. Incidence, mortality, and SMR of osteoporotic fractures in RA patients and the general population were calculated and compared. Results: Osteopororic fractures in the general population and RA patients were increased by 11.6% and 17.4% over 3 years (195,271 and 1,356 in 2010; 217,985 and 1,592 in 2012), respectively. Mean age-specific incidence of osteoporotic fracture in women and men with RA increased from 932.1/100,000 and 306.1/100,000 for aged 50 to 59 year to 9,377.0/100,000 and 3,700.9/100,000 for aged ≥80 years, respectively. Cumulative mortality rate in the first year after osteoporotic fracture in patients with RA was higher than that in the general population (7.8% in RA and 6.6% in the general population). SMR of osteoporotic fracture in RA patients was 1.4 times higher in men and 1.3 times higher in women than that for the general population. Conclusions: This study demonstated that incidence, 1-year mortality, and SMR of osteoporotic fracture in RA patients aged 50 years and older were higher than those in the general papulation. Copyright © 2019 The Korean Society for Bone and Mineral Research.
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