비스테로이드소염제 관련 소화성궤양의 예방과 치료 가이드라인Guidelines of Prevention and Treatment for NSAID-related Peptic Ulcers
- Authors
- 이준행; 이용찬; 전성우; 김정욱; 이상우
- Issue Date
- Nov-2009
- Publisher
- 대한소화기학회
- Keywords
- Non-steroidal anti-inflammatory drug; Peptic ulcer; Prevention; Guideline
- Citation
- 대한소화기학회지, v.54, no.5, pp 309 - 317
- Pages
- 9
- Journal Title
- 대한소화기학회지
- Volume
- 54
- Number
- 5
- Start Page
- 309
- End Page
- 317
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/33293
- DOI
- 10.4166/kjg.2009.54.5.309
- ISSN
- 1598-9992
2233-6869
- Abstract
- Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used medications in Korea. Gastrointestinal toxicity, including peptic ulcer, is a common adverse effect of NSAIDs. Risk factors for NSAID-related peptic ulcer include a previous history of peptic ulcer, advanced age, high dose, concomitant use of corticosteroids, anticoagulants, other NSAIDs including low-dose aspirin. Preventive measure(s), such as COX-2 inhibitor, proton pump inhibitor or misoprostrol, should be done for patients requiring NSAID therapy who have high-risk factor(s) for peptic ulcer. Low dose aspirin also increases the risk of peptic ulcer, so preventive measure(s) should be done for high-risk patients. The eradication of Helicobacter pylori is recommended for high-risk NSAID-users. Treatment strategies for peptic ulcers in NSAID users are mostly the same for peptic ulcers in NSAID non-users.
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