아토피피부염 환자에서 민들레 추출물 함유제(AF-343)의 효과에 관한 연구
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김지현 | - |
dc.contributor.author | 이혜인 | - |
dc.contributor.author | 박주희 | - |
dc.contributor.author | 임윤영 | - |
dc.contributor.author | 김범준 | - |
dc.contributor.author | 임인석 | - |
dc.contributor.author | 김명남 | - |
dc.contributor.author | 김현석 | - |
dc.contributor.author | 김종근 | - |
dc.contributor.author | 한성훈 | - |
dc.contributor.author | 조수묵 | - |
dc.contributor.author | 김재현 | - |
dc.contributor.author | 박기문 | - |
dc.date.available | 2019-08-16T02:59:02Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1226-8739 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/33751 | - |
dc.description.abstract | Background: Taraxacum platycarpum has been investigated for its antiallergic activity in bronchial asthma, but few studies have been conducted to evaluate its efficacy for the treatment of atopic dermatitis (AD). Objective: This study was designed to evaluate the efficacy of the extracts of Taraxacum platycarpum (AF-343) for the treatment of AD. Method: Seventy-five patients with AD were randomly assigned either to a low-dose, high-dose or control groups. AF-343 and placebo were ingested for 8 weeks. The SCORing Atopic Dermatitis (SCORAD) scores, skin hydration, transepidermal water loss (TEWL), eosinophil, total IgE, eosinophil catinonic protein and cytokines were measured before and at the end of treatment. Result: A significant reduction in the SCORAD scores at the end of treatment were observed in the control, low-dose and high-dose groups when compared with the initial scores (P=0.028, P<0.001 and P<0.001, respectively). High-dose treatment increased the skin hydration (P=0.013), but no significant change was observed in the low-dose and control groups (P=0.056 and P=0.624, respectively). The low-dose and high-dose treatment groups showed a significant reduction of TEWL from baseline (P=0.002 and P=0.031, respectively). High-dose treatment induced an increase in eotaxin and a decrease in IL-5 (P=0.021 and P=0.028, respectively). Conclusion: These results show that AF-343 treatment can improve the severity and skin hydration in patients with mild AD. | - |
dc.format.extent | 7 | - |
dc.publisher | 대한천식알레르기학회 | - |
dc.title | 아토피피부염 환자에서 민들레 추출물 함유제(AF-343)의 효과에 관한 연구 | - |
dc.title.alternative | The Effect of the Extracts of Taraxacum platycarpum (AF-343) in Atopic Dermatitis | - |
dc.type | Article | - |
dc.identifier.bibliographicCitation | 천식 및 알레르기, v.30, no.1, pp 36 - 42 | - |
dc.identifier.kciid | ART001429934 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 42 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 36 | - |
dc.citation.title | 천식 및 알레르기 | - |
dc.citation.volume | 30 | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Taraxacum platycarpum | - |
dc.subject.keywordAuthor | Atopic dermatitis | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.