아토피피부염 환자에서 민들레 추출물 함유제(AF-343)의 효과에 관한 연구The Effect of the Extracts of Taraxacum platycarpum (AF-343) in Atopic Dermatitis
- Authors
- 김지현; 이혜인; 박주희; 임윤영; 김범준; 임인석; 김명남; 김현석; 김종근; 한성훈; 조수묵; 김재현; 박기문
- Issue Date
- 2010
- Publisher
- 대한천식알레르기학회
- Keywords
- Taraxacum platycarpum; Atopic dermatitis
- Citation
- 천식 및 알레르기, v.30, no.1, pp 36 - 42
- Pages
- 7
- Journal Title
- 천식 및 알레르기
- Volume
- 30
- Number
- 1
- Start Page
- 36
- End Page
- 42
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/33751
- ISSN
- 1226-8739
- Abstract
- Background: Taraxacum platycarpum has been investigated for its antiallergic activity in bronchial asthma, but few studies have been conducted to evaluate its efficacy for the treatment of atopic dermatitis (AD).
Objective: This study was designed to evaluate the efficacy of the extracts of Taraxacum platycarpum (AF-343) for the treatment of AD.
Method: Seventy-five patients with AD were randomly assigned either to a low-dose, high-dose or control groups. AF-343 and placebo were ingested for 8 weeks. The SCORing Atopic Dermatitis (SCORAD) scores, skin hydration, transepidermal water loss (TEWL), eosinophil, total IgE, eosinophil catinonic protein and cytokines were measured before and at the end of treatment.
Result: A significant reduction in the SCORAD scores at the end of treatment were observed in the control, low-dose and high-dose groups when compared with the initial scores (P=0.028, P<0.001 and P<0.001, respectively). High-dose treatment increased the skin hydration (P=0.013), but no significant change was observed in the low-dose and control groups (P=0.056 and P=0.624, respectively). The low-dose and high-dose treatment groups showed a significant reduction of TEWL from baseline (P=0.002 and P=0.031, respectively). High-dose treatment induced an increase in eotaxin and a decrease in IL-5 (P=0.021 and P=0.028, respectively).
Conclusion: These results show that AF-343 treatment can improve the severity and skin hydration in patients with mild AD.
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