Effects of Rutaecarpine on the Pharmacokinetics of Caffeine and Its Three Metabolites in Rats
- Authors
- Young Min Seo; 노금한; Min Jeong Kong; Dae Hun Lee; Mi Jeong Kang; 장영동; 강원구; 정병선; 정태천
- Issue Date
- Apr-2011
- Publisher
- 한국응용약물학회
- Keywords
- Rutaecarpine; Caffeine; Pharmacokinetics; Intravenous; Rat; In vivo
- Citation
- Biomolecules & Therapeutics, v.19, no.2, pp 243 - 247
- Pages
- 5
- Journal Title
- Biomolecules & Therapeutics
- Volume
- 19
- Number
- 2
- Start Page
- 243
- End Page
- 247
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/33909
- ISSN
- 1976-9148
2005-4483
- Abstract
- Rutaecarpine, an alkaloid originally isolated from the unripe fruit of Evodia rutaecarpa, has been shown to be anti-infl ammatory. In the present study, a possible interaction between rutaecarpine and caffeine was investigated in male Sprague Dawley rats. Twenty four hr after the oral pretreatment with rutaecarpine at 80 mg/kg for three consecutive days, rats were treated intravenously with 10 mg/kg of caffeine. Compared with control rats, the pharmacokinetic parameters of caffeine in rutaecarpine-pretreated rats were signifi cantly changed, possibly due to the rapid metabolism. The production of three metabolites of caffeine (i.e., paraxanthine,theobromine and theophylline) was also signifi cantly changed in rats pretreated with rutaecarpine. The present results suggest that oral rutaecarpine would change the intravenous pharmacokinetic characteristics of caffeine.
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