Antioxidative and Antidiarrheal Effects of Persimmon Extracts
- Authors
- 박동선; Sun Hee Lee; Dae-Kwon Bae; Young Jin Choi; Tea Kyun Kim; Yun-Hui Yang; Goeun Yang; Sang-Chul Kwon; 이도익; 주성수; 김윤배
- Issue Date
- 2010
- Publisher
- 한국실험동물학회
- Keywords
- Persimmon; antioxidative activity; antidiarrheal activity; gastrointestinal motility
- Citation
- Laboratory Animal Research, v.26, no.4, pp 407 - 413
- Pages
- 7
- Journal Title
- Laboratory Animal Research
- Volume
- 26
- Number
- 4
- Start Page
- 407
- End Page
- 413
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/34532
- ISSN
- 1738-6055
- Abstract
- Since oxidative stresses are involved in gastroenteritis and diarrhea, we investigated antioxidative and antidiarrheal activities of persimmon flesh extract (PFE) and persimmon calyx extract (PCE) in vitro and in vivo, respectively. PCE significantly scavenged 1,1-diphenyl-2-picrylhydrazyl hydrate and 2,2'-azinobis (3-ethylbenzthiazoline-6-sulfonic acid) from 500 μg/mL, although PFE was ineffective. In addition, PFE and PCE exhibited strong nitric oxide-scavenging effects from 1 μg/mL, in which PCE was superior to ascorbic acid (50 μM). Furthermore, PFE and PCE significantly inhibited FeCl3-induced lipid peroxidation as well as Cu2+/H2O2-induced protein oxidation from 10 μg/mL. In vivo charcoal-propulsion assay, in contrast to a negligible effect of PFE, treatment with PCE (160-500 mg/kg) markedly inhibited intestinal motility. The results indicate that extracts of persimmon, especially PCE, possess antioxidative, antiinflammatory and antidiarrheal activities. Therefore, it is suggested that persimmon extracts could be used for the relief of gastroenteritis and diarrhea.
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