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Effect of endocrine disruptors on the ratio of X and Y chromosome-bearing live spermatozoa

Authors
Song, W.-H.Mohamed, E.A.Pang, W.-K.Kang, K.-H.Ryu, D.-Y.Rahman, M.S.Pang, M.-G.
Issue Date
Dec-2018
Publisher
Elsevier Inc.
Keywords
Spermatozoa; Sperm functions; Sex chromosome; Endocrine-disrupting chemical; Sex ratio
Citation
Reproductive Toxicology, v.82, pp 10 - 17
Pages
8
Journal Title
Reproductive Toxicology
Volume
82
Start Page
10
End Page
17
URI
https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/3458
DOI
10.1016/j.reprotox.2018.09.002
ISSN
0890-6238
Abstract
Although equal numbers of X and Y spermatozoa are produced during spermatogenesis, the sex chromosome ratio in ejaculated spermatozoa can be altered by exposure to endocrine-disrupting chemicals (EDCs), which can be reflected by altered sex ratios at birth. Here, we hypothesized EDCs affect sperm functions and viability of X and Y chromosome-bearing human spermatozoa. After exposure to genistein (Gen), bisphenol A (BPA), 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), dibromochloropropane (DBCP), and diazinon (Diaz), we evaluated motility, viability, capacitation, and differential viability of X and Y spermatozoa. All EDCs tested altered sperm viability, motility, and capacitation. Interestingly, the Y/X ratio of live spermatozoa was significantly lower in sperm treated with TCDD, DBCP, and Diaz than control spermatozoa. Our results suggest that some of EDCs have larger effects on the viability of Y spermatozoa than X spermatozoa, implicating that a reduction in Y sperm viability may result in a female-biased sex ratio of offspring at birth. © 2018 Elsevier Inc.
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대학원 (동물생명공학과.)
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