화이트 칼라소재의 알도즈 환원효소 억제작용 탐색

Abstract

The purpose of this study was to evaluate the potential of naturally occurring aldose reductase (AR) inhibitors from white-color natural products (Aruncus dioicus var. kamtschaticus, Chionanthus retusa, Cosmos bipinnatus, Hibiscus syriacus, Hydrangea paniculata, Magnolia denudata, Prunus padus, Robinia pseudo-accacia, Rhododendron mucronulatum for. albiflorum, Spiraea blumei, and Spiraea prunifolia var. simpliciflora). The MeOH extract of white-color natural products were tested on rat lens AR inhibition in vitro. Among them, the MeOH extract of R. mucronulatum for. albiflorum showed highest inhibition on AR (IC50 value, 1.07 μg/ml). These results suggested that R. mucronulatum for. albiflorum,a white-color natural product, could be a useful resource in the development of a novel AR inhibitory agent against diabetic complications.