민속식물의 라디칼 소거능 및 위암예방효과 탐색

Abstract

This study was conducted to screen of Korean folk plants (KFP) with radical scavenging effect and prevention effect from gastric cancer. Scavenging activities on 1,1-diphenyl-2-picrylhydrazyl (DPPH) and hydroxyl radical (ㆍOH), microbial inhibition activity against Helicobacter pylori (H. pylori) and growth inhibitory effects in human gastric adenocarcinoma cells (AGS) were investigated. In DPPH scavenging activity at 50μg/ml, 18 plants showed over 80% scavenging activity, particularly Adriana acerifolia (leaf and branch) and Camellia synaptica (leaf, branch and seed) showed over 90% scavenging effect against DPPH. In addition, Chrysanthemum boreale (leaf and branch), Zanthoxylum schinifolium (branch), Clerodendrum trichotomum (branch), Rumex crispus (rachis), Sambucuss williamsii var. coreana (unbloom flower), Lespedeza cuneate (branch), Chrysanthemum indicum (flower) and Hibiscus hamabo (leaf) showed over 60% ㆍOH scavenging activity at 100μg/ml. Z. schinifolium (branch) showed the strongest antimicrobial activity (clear zone＞17 mm) against H. pylori and the 15 plants including Z. schinifolium (branch), showed strong antimicrobial effect (clear zone ＞11 mm) at 10 μg/30μl. C. indicum (flower), Cedrela sinensis (leaf), Chrysanthemum pallasianum (leaf and branch), Adriana acerifolia (leaf and branch), Antithriscus sylvestris, Allium victorialis var. platyphyllum and Chelidonium majus var. asiaticum inhibited the growth of AGS cell by up to 80% at 100μg/ml. In conclusion, Among KFP, Z. schinifolium (branch), C. boreale (leaf and branch), C. indicum (flower) and A. tataricus (flower) showed strong radical scavenging activity and prevention effect against H. pylori and gastric cancer, suggesting as new resources for development of many purposes including functional food or drug with preventive effect from degenerative diseases. (Cancer Prev Res 16, 65-73, 2011)