12주 OROS-Methylphenidate 약물 치료 후 ADHD 아동의 삶의 질 변화Change of Quality of Life in Children with ADHD after 12 Weeks OROS-Methylphenidate Treatment
- Authors
- 김형인; 김붕년; 조수철; 신민섭; 유희정; 김재원; 김지훈; 손정우; 신윤미; 정운선; 한덕현
- Issue Date
- 2012
- Publisher
- 대한소아청소년 정신의학회
- Keywords
- 삶의 질; 메틸페니데이트; 주의력결핍 과잉행동장애; Quality of Life; Methylphenidate; Attention-Deficit Hyperactivity Disorder
- Citation
- 소아 청소년 정신의학, v.23, no.3, pp 103 - 108
- Pages
- 6
- Journal Title
- 소아 청소년 정신의학
- Volume
- 23
- Number
- 3
- Start Page
- 103
- End Page
- 108
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/35439
- ISSN
- 1225-729X
2233-9183
- Abstract
- Objectives:The aim of this study is to investigate the effectiveness of treatment with osmotic-release oral system methylphenidate (OROS-MPH) on quality of life (QOL) in children with attention-deficit hyperactivity disorder (ADHD). Another aim is to assess the relationship between change in QOL and other factors including children’s symptoms and academic performance or parents’ depression and parenting stress.
Methods:A total of 111 medication-naïve children with ADHD in a multicenter, open-label, 12-week trial of OROS-MPH completed an evaluation using diverse rating scales at two time points; at baseline and after 12 weeks of treatment. Scales for investigation of children included the Parent Report Form-Children’s Health and Illness Profile-Children’s Edition (PRF-CHIP-CE) on QOL, the ADHD Rating Scale-IV on symptoms, and the Academic Performance Rating Scale (APRS). The Beck Depression Inventory and Parenting Stress Index were used for assessment of their parents.
Results:Total scores for mean PRF-CHIP-CE increased from 207.9±26.7 at baseline to 226.3±25.9 after 12 weeks of treatment (p<.001). The change of APRS showed the strongest correlation with the increment of PRF-CHIP-CE scores (Pearson coefficient=0.561, p<.001), even after controlling for other factors (partial correlation coefficient=0.420, p<.001).
Conclusion:Treatment with MPH-OROS results in improvement of QOL in children with ADHD in Korea. The advance in academic performance plays a key role in this change of QOL.
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