마우스 간염바이러스(MHV-2)에 의해 유발된 전격성 바이러스간염에 대한 비페닐메칠디카르복실레이트/아만타딘제제의 간보호 및 잠재적 항바이러스효과Hepatoprotective and a Potential Antiviral Effect of Biphenyl Dimethyl Dicarboxylate/Amantadine for an Acute Viral Hepatitis Induced by MHV-2 in ICR Mice
- Authors
- 주성수; 진혁준; 원태준; 장수길; 황광우; 이도익
- Issue Date
- 2007
- Publisher
- 대한약학회
- Keywords
- MHV-2; dimethyl dicarboxylate; amantadine; HBV; ICR mouse; lamivudine
- Citation
- 약 학 회 지, v.51, no.3, pp 194 - 198
- Pages
- 5
- Journal Title
- 약 학 회 지
- Volume
- 51
- Number
- 3
- Start Page
- 194
- End Page
- 198
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/35997
- ISSN
- 0377-9556
- Abstract
- The mouse hepatitis virus (MHV-2) induces broad collapses, focal necrosis and cytolysis of hepatocytes, and
leads to death after three to five days of intraperitoneal injection in mice. The present study investigated whether the combinatorial
treatment of dimethyl dicarboxylate/amantadine (2 : 1) showed hepatoprotective and/or antiviral properties in
MHV-2 infected ICR mice. In the study, we found that dimethyl dicarboxylate/amantadine group (VDDBA) increased the
survival rate (30.8%) when compared to positive control, VL (7.7%) and that VDDBA lengthened the survival time (4.2 d)
after MHV-2 infection. In addition, ALT and AST were well regulated when treated with VDDBA (p<0.01). Finally, we concluded
that those results were probably from the inhibition of viral replication and at least antiproliferative effect on MHV-2.
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