Neurotoxic Effects of Tetrahydroisoquinolines and Underlying Mechanisms
- Authors
- 서용준; 김현정
- Issue Date
- 2010
- Publisher
- 한국뇌신경과학회
- Keywords
- tetrahydroisoquinoline; neurotoxicity; cell death; reactive oxygen species; Parkinson; alcoholism
- Citation
- Experimental Neurobiology, v.19, no.2, pp 63 - 70
- Pages
- 8
- Journal Title
- Experimental Neurobiology
- Volume
- 19
- Number
- 2
- Start Page
- 63
- End Page
- 70
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/36209
- ISSN
- 1226-2560
2093-8144
- Abstract
- Tetrahydropapaveroline (THP), a neurotoxic tetrahydroisoquinoline alkaloid formed by condensation between dopamine and dopaldehyde, has been speculated to cause Parkinson's disease and also to contribute to alcohol dependence. Having two catechol moieties, THP may readily undergo oxidation to form an o-quinone intermediate with concomitant production of reactive oxygen species, which can cause neuronal cell death and DNA damage. This review will deal with the current knowledge of neurotoxic effects of this endogenous alkaloid and underlying biochemical mechanisms.
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