Poisonous Caterpillar-Inspired Chitosan Nanofiber Enabling Dual Photothermal and Photodynamic Tumor Ablation
- Authors
- Yu, Hyeong Sup; Park, Hongsuk; Thang Hong Tran; Hwang, Sung Yeon; Na, Kun; Lee, Eun Seong; Oh, Kyung Taek; Oh, Dongyeop X.; Park, Jeyoung
- Issue Date
- Jun-2019
- Publisher
- MDPI
- Keywords
- pH-sensitive chitosan nanofiber; photothermal gold nanoparticles; photodynamic chlorin e6; synergistic tumor therapy; tumor-targeted drug delivery system
- Citation
- PHARMACEUTICS, v.11, no.6
- Journal Title
- PHARMACEUTICS
- Volume
- 11
- Number
- 6
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/36453
- DOI
- 10.3390/pharmaceutics11060258
- ISSN
- 1999-4923
- Abstract
- As caterpillars detect the presence of predators and secrete poison, herein, we show an innovative and highly effective cancer therapeutic system using biocompatible chitosan nanofiber (CNf) installed with a pH-responsive motif that senses tumor extracellular pH, pH(e), prior to delivering dual-modal light-activatable materials for tumor reduction. The filamentous nanostructure of CNf is dynamic during cell interaction and durable in blood circulation. Due to its amine group, CNf uptakes a large amount of photothermal gold nanoparticles (AuNPs, >25 wt %) and photodynamic chlorin e6 (Ce6, >5 wt %). As the innovative CNf approaches tumors, cationic CNf effectively discharges AuNPs connected to the pH-responsive motif via electrostatic repulsion and selectively binds to tumor cells that are generally anionic, via the electrostatic attraction accompanied by CNf. We demonstrated via these actions that the endocytosed Ce6 (on CNf) and AuNPs (free from CNf) significantly elicited tumor cell death under light irradiation. As a result, the synergistic interplay of thermogenesis and photodynamic action was observed to switch on at the pH(e), resulting in a striking reduction in tumor formation and growth rate upon light exposure.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/36453)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.