The calcium sensor CBL10 mediates salt tolerance by regulating ion homeostasis in Arabidopsisopen access
- Authors
- Kim, Beom-Gi; Waadt, Rainer; Cheong, Yong Hwa; Pandey, Girdhar K.; Dominguez-Solis, Jose R.; Schueltke, Stefanie; Lee, Sung Chul; Kudla, Joerg; Luan, Sheng
- Issue Date
- Nov-2007
- Publisher
- WILEY
- Keywords
- calcium sensor; salt stress; signal transduction; protein kinase; tonoplast
- Citation
- PLANT JOURNAL, v.52, no.3, pp 473 - 484
- Pages
- 12
- Journal Title
- PLANT JOURNAL
- Volume
- 52
- Number
- 3
- Start Page
- 473
- End Page
- 484
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/36535
- DOI
- 10.1111/j.1365-313X.2007.03249.x
- ISSN
- 0960-7412
1365-313X
- Abstract
- Calcium serves as a critical messenger in many adaptation and developmental processes. Cellular calcium signals are detected and transmitted by sensor molecules such as calcium-binding proteins. In plants, the calcineurin B-like protein (CBL) family represents a unique group of calcium sensors and plays a key role in decoding calcium transients by specifically interacting with and regulating a family of protein kinases (CIPKs). We report here that the CBL protein CBL10 functions as a crucial regulator of salt tolerance in Arabidopsis. Cbl10 mutant plants exhibited significant growth defects and showed hypersensitive cell death in leaf tissues under high-salt conditions. Interestingly, the Na+ content of the cbl10 mutant, unlike other salt-sensitive mutants identified thus far, was significantly lower than in the wild type under either normal or high-salt conditions, suggesting that CBL10 mediates a novel Ca2+-signaling pathway for salt tolerance. Indeed, the CBL10 protein physically interacts with the salt-tolerance factor CIPK24 (SOS2), and the CBL10-CIPK24 (SOS2) complex is associated with the vacuolar compartments that are responsible for salt storage and detoxification in plant cells. These findings suggest that CBL10 and CIPK24 (SOS2) constitute a novel salt-tolerance pathway that regulates the sequestration/compartmentalization of Na+ in plant cells. Because CIPK24 (SOS2) also interacts with CBL4 (SOS3) and regulates salt export across the plasma membrane, our study identifies CIPK24 (SOS2) as a multi-functional protein kinase that regulates different aspects of salt tolerance by interacting with distinct CBL calcium sensors.
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