TiO2 particles induce ER stress and apoptosis in human hepatoma cells, HepG2, in a particle size-dependent manner
DC Field | Value | Language |
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dc.contributor.author | Song, Ha Na | - |
dc.contributor.author | Jang, Su Kyung | - |
dc.contributor.author | Hwang, Ok Kyung | - |
dc.contributor.author | Lee, Hong Jin | - |
dc.contributor.author | Chun, Hyang Sook | - |
dc.date.available | 2019-10-24T05:40:08Z | - |
dc.date.issued | 2019-12 | - |
dc.identifier.issn | 1226-7708 | - |
dc.identifier.issn | 2092-6456 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/36897 | - |
dc.description.abstract | The cytotoxicity of TiO2 nanoparticles are well-known, but the particle size-dependent induction of ER stress and apoptosis by TiO2 in hepatocytes has not been elucidated clearly. In the present study, we investigated whether a fine TiO2 particle and two types of TiO2 nanoparticles induce ER stress and apoptosis differently in HepG2 cells. A particle size-dependent decrease in cell viability was observed after exposure to the TiO2 particles. The levels of ER stress-related proteins (BiP, CHOP, ATF6α, and p-PERK) were increased with decreasing particle size. TiO2 particles induced ER stress-mediated apoptosis in a particle size-dependent manner as seen by a decrease in the expression of Bcl-2, and increases in the expression of Bax, caspase-12, and cleaved caspase-3. These results indicated that the cytotoxicity produced by TiO2 particles was related to particle size, with smaller TiO2 nanoparticles producing greater toxic effects involving ER stress and apoptosis in the HepG2 cells. © 2019, The Korean Society of Food Science and Technology. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | The Korean Society of Food Science and Technology | - |
dc.title | TiO2 particles induce ER stress and apoptosis in human hepatoma cells, HepG2, in a particle size-dependent manner | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s10068-019-00623-7 | - |
dc.identifier.bibliographicCitation | Food Science and Biotechnology, v.28, no.6, pp 1907 - 1917 | - |
dc.identifier.kciid | ART002532998 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000496753800034 | - |
dc.identifier.scopusid | 2-s2.0-85071492173 | - |
dc.citation.endPage | 1917 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1907 | - |
dc.citation.title | Food Science and Biotechnology | - |
dc.citation.volume | 28 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | ER | - |
dc.subject.keywordAuthor | HepG2 | - |
dc.subject.keywordAuthor | Size-dependent | - |
dc.subject.keywordAuthor | TiO2 | - |
dc.subject.keywordPlus | Cell death | - |
dc.subject.keywordPlus | Erbium | - |
dc.subject.keywordPlus | Nanoparticles | - |
dc.subject.keywordPlus | Particle size | - |
dc.subject.keywordPlus | Silicon compounds | - |
dc.subject.keywordPlus | Titanium dioxide | - |
dc.subject.keywordPlus | Cell viability | - |
dc.subject.keywordPlus | Hep-g2 cells | - |
dc.subject.keywordPlus | Hepatocytes | - |
dc.subject.keywordPlus | HepG2 | - |
dc.subject.keywordPlus | Human hepatoma cells | - |
dc.subject.keywordPlus | Size dependent | - |
dc.subject.keywordPlus | TiO2 | - |
dc.subject.keywordPlus | Toxic effect | - |
dc.subject.keywordPlus | TiO2 nanoparticles | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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