RNase G controls tpiA mRNA abundance in response to oxygen availability in Escherichia coli
DC Field | Value | Language |
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dc.contributor.author | Lee ,Jaejin | - |
dc.contributor.author | Lee, Dong-Ho | - |
dc.contributor.author | Jeon, Che Ok | - |
dc.contributor.author | Lee, Kangseok | - |
dc.date.available | 2019-11-18T11:40:43Z | - |
dc.date.issued | 2019-10 | - |
dc.identifier.issn | 1225-8873 | - |
dc.identifier.issn | 1976-3794 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/36988 | - |
dc.description.abstract | Studies have shown that many enzymes involved in glycolysis are upregulated in Escherichia coli endoribonuclease G (rng) null mutants. However, the molecular mechanisms underlying the RNase G-associated regulation of glycolysis have not been characterized. Here, we show that RNase G cleaves the 5′ untranslated region of triosephosphate isomerase A (tpiA) mRNA, leading to destabilization of the mRNA in E. coli. Nucleotide substitutions within the RNase G cleavage site in the genome resulted in altered tpiA mRNA stability, indicating that RNase G activity influences tpiA mRNA abundance. In addition, we observed that tpiA expression was enhanced, whereas that of RNase G was decreased, in E. coli cells grown anaerobically. Our findings suggest that RNase G negatively regulates tpiA mRNA abundance in response to oxygen availability in E. coli. © 2019, The Microbiological Society of Korea. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Microbiological Society of Korea | - |
dc.title | RNase G controls tpiA mRNA abundance in response to oxygen availability in Escherichia coli | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s12275-019-9354-6 | - |
dc.identifier.bibliographicCitation | Journal of Microbiology, v.57, no.10, pp 910 - 917 | - |
dc.identifier.kciid | ART002509135 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000491073300010 | - |
dc.identifier.scopusid | 2-s2.0-85072762150 | - |
dc.citation.endPage | 917 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 910 | - |
dc.citation.title | Journal of Microbiology | - |
dc.citation.volume | 57 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | glycolysis | - |
dc.subject.keywordAuthor | mRNA abundance | - |
dc.subject.keywordAuthor | RNase G | - |
dc.subject.keywordAuthor | rng | - |
dc.subject.keywordAuthor | tpiA | - |
dc.subject.keywordPlus | CAFA PROTEIN | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | RRAA | - |
dc.subject.keywordPlus | DECAY | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | RIBONUCLEASE | - |
dc.subject.keywordPlus | INHIBITOR | - |
dc.subject.keywordPlus | CLEAVAGE | - |
dc.subject.keywordPlus | BACTERIA | - |
dc.subject.keywordPlus | ENOLASE | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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