Constituents from Scutellaria barbata Inhibiting Nitric Oxide Production in LPS-Stimulated Microglial Cells
DC Field | Value | Language |
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dc.contributor.author | Lee, So Ra | - |
dc.contributor.author | Kim, Min-Suk | - |
dc.contributor.author | Kim, Sunggun | - |
dc.contributor.author | Hwang, Kwang Woo | - |
dc.contributor.author | Park, So-Young | - |
dc.date.available | 2019-03-08T07:38:04Z | - |
dc.date.issued | 2017-11 | - |
dc.identifier.issn | 1612-1872 | - |
dc.identifier.issn | 1612-1880 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/3716 | - |
dc.description.abstract | The arial parts of Scutellaria barbata D. Don (Lamiaceae) efficiently inhibited NO production in BV2 microglial cells, and the active constituents were further isolated based on activity-guided isolation using silica-gel column chromatography, RP-C18 MPLC and prep-HPLC. As the results, 2 flavonoids including 6-methoxynaringenin (1) and 6-O-methylscutellarein (5), and 6 neo-clerodane diterpenes such as scutebarbatine W (2), scutebatas B (3), scutebarbatine B (4), scutebarbatine A (6), 6-O-nicotinolylscutebarbatine G (7), and scutebarbatine X (8) were isolated. The structures of these compounds were elucidated based on NMR and MS data, and the comparison of literature values. All the compounds except compound 7 inhibited NO production efficiently with IC50 values of lower than 50m. Particularly, compounds 1 and 8 were the most efficient with IC50 values of 25.8 and 27.4m, respectively. This is the first report suggesting the potential of S.barbata on the reduction of neuroinflammation. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Constituents from Scutellaria barbata Inhibiting Nitric Oxide Production in LPS-Stimulated Microglial Cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/cbdv.201700231 | - |
dc.identifier.bibliographicCitation | CHEMISTRY & BIODIVERSITY, v.14, no.11 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000416313000006 | - |
dc.identifier.scopusid | 2-s2.0-85032972370 | - |
dc.citation.number | 11 | - |
dc.citation.title | CHEMISTRY & BIODIVERSITY | - |
dc.citation.volume | 14 | - |
dc.type.docType | Article | - |
dc.publisher.location | 독일 | - |
dc.subject.keywordAuthor | Scutellaria barbata | - |
dc.subject.keywordAuthor | nitric oxide | - |
dc.subject.keywordAuthor | microglial cells | - |
dc.subject.keywordAuthor | natural products | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordPlus | D. DON | - |
dc.subject.keywordPlus | NEOCLERODANE DITERPENOIDS | - |
dc.subject.keywordPlus | TOTAL FLAVONOIDS | - |
dc.subject.keywordPlus | CYTOTOXIC ACTIVITIES | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | HEPATOCARCINOMA | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | PROTECTS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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