Constituents from Scutellaria barbata Inhibiting Nitric Oxide Production in LPS-Stimulated Microglial Cells
- Authors
- Lee, So Ra; Kim, Min-Suk; Kim, Sunggun; Hwang, Kwang Woo; Park, So-Young
- Issue Date
- Nov-2017
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- Scutellaria barbata; nitric oxide; microglial cells; natural products; inflammation
- Citation
- CHEMISTRY & BIODIVERSITY, v.14, no.11
- Journal Title
- CHEMISTRY & BIODIVERSITY
- Volume
- 14
- Number
- 11
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/3716
- DOI
- 10.1002/cbdv.201700231
- ISSN
- 1612-1872
1612-1880
- Abstract
- The arial parts of Scutellaria barbata D. Don (Lamiaceae) efficiently inhibited NO production in BV2 microglial cells, and the active constituents were further isolated based on activity-guided isolation using silica-gel column chromatography, RP-C18 MPLC and prep-HPLC. As the results, 2 flavonoids including 6-methoxynaringenin (1) and 6-O-methylscutellarein (5), and 6 neo-clerodane diterpenes such as scutebarbatine W (2), scutebatas B (3), scutebarbatine B (4), scutebarbatine A (6), 6-O-nicotinolylscutebarbatine G (7), and scutebarbatine X (8) were isolated. The structures of these compounds were elucidated based on NMR and MS data, and the comparison of literature values. All the compounds except compound 7 inhibited NO production efficiently with IC50 values of lower than 50m. Particularly, compounds 1 and 8 were the most efficient with IC50 values of 25.8 and 27.4m, respectively. This is the first report suggesting the potential of S.barbata on the reduction of neuroinflammation.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.