Aquilanols A and B, Macrocyclic Humulene-Type Sesquiterpenoids from the Agarwood of Aquilaria malaccensis
- Authors
- Chi Thanh Ma; Eom, Taeyong; Cho, Eunji; Wu, Bo; Kim, Tae Ryong; Oh, Ki Bong; Han, Sang Beom; Kwon, Sung Won; Park, Jeong Hill
- Issue Date
- Nov-2017
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF NATURAL PRODUCTS, v.80, no.11, pp 3043 - 3048
- Pages
- 6
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- Volume
- 80
- Number
- 11
- Start Page
- 3043
- End Page
- 3048
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/3721
- DOI
- 10.1021/acs.jnatprod.7b00462
- ISSN
- 0163-3864
1520-6025
- Abstract
- Four new and five known sesquiterpenoids were isolated from the agarwood of Aquilaria malaccensis. Aquilanols A and B (1 and 2) have an unprecedented macrocyclic humulene structure with a bicyclic 7/10 ring system. Compound 2 was obtained as a scalemic mixture that was resolved by HPLC analysis using a chiral column. Their structures were deduced based on spectroscopic data analysis, and the absolute configurations were unambiguously determined by X-ray crystallographic data and ECD spectroscopic analysis. A putative biosynthetic pathway of these sesquiterpenoids is proposed.
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