Requirement of Pretone by Thromboxane A2 for Hypoxic Pulmonary Vasoconstriction in Precision-cut Lung Slices of Rat
DC Field | Value | Language |
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dc.contributor.author | Park, Su Jung | - |
dc.contributor.author | Yoo, Hae Young | - |
dc.contributor.author | Kim, Hye Jin | - |
dc.contributor.author | Kim, Jin Kyoung | - |
dc.contributor.author | Zhang, Yin-Hua | - |
dc.contributor.author | Kim, Sung Joon | - |
dc.date.available | 2020-01-03T06:40:21Z | - |
dc.date.issued | 2012-02 | - |
dc.identifier.issn | 1226-4512 | - |
dc.identifier.issn | 2093-3827 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/37230 | - |
dc.description.abstract | Hypoxic pulmonary vasoconstriction (HPV) is physiologically important response for preventing mismatching between ventilation and perfusion in lungs. The HPV of isolated pulmonary arteries (HPV-PA) usually require a partial pretone by thromboxane agonist (U46619). Because the HPV of ventilated/perfused lungs (HPV-lung) can be triggered without pretone conditioning, we suspected that a putative tissue factor might be responsible for the pretone of HPV. Here we investigated whether HPV can be also observed in precision-cut lung slices (PCLS) from rats. The HPV in PCLS also required partial contraction by U46619. In addition, K+ channel blockers (4AP and TEA) required U46619-pretone to induce significant contraction of PA in PCLS. In contrast, the airways in PCLS showed reversible contraction in response to the K+ channel blockers without pretone conditioning. Also, the airways showed no hypoxic constriction but a relaxation under the partial pretone by U46619. The airways in PCLS showed reliable, concentration-dependent contraction by metacholine (EC50, ∼210nM). In summary, the HPV in PCLS is more similar to isolated PA than V/P lungs. The metacholineinduced constriction of bronchioles suggested that the PLCS might be also useful for studying airway physiology in situ. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한약리학회 | - |
dc.title | Requirement of Pretone by Thromboxane A2 for Hypoxic Pulmonary Vasoconstriction in Precision-cut Lung Slices of Rat | - |
dc.type | Article | - |
dc.identifier.bibliographicCitation | The Korean Journal of Physiology & Pharmacology, v.16, no.1, pp 59 - 64 | - |
dc.identifier.kciid | ART001636739 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000301565800009 | - |
dc.identifier.scopusid | 2-s2.0-84863380374 | - |
dc.citation.endPage | 64 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 59 | - |
dc.citation.title | The Korean Journal of Physiology & Pharmacology | - |
dc.citation.volume | 16 | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Lung slice | - |
dc.subject.keywordAuthor | Hypoxic pulmonary vasoconstriction | - |
dc.subject.keywordAuthor | Thromboxane A2 | - |
dc.subject.keywordAuthor | Airway smooth muscle | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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