One-pot synthesis of carbon dots with intrinsic folic acid for synergistic imaging-guided photothermal therapy of prostate cancer cells
- Authors
- Phan, Le Minh Tu; Gul, Anam Rana; Le, Thi Ngoc; Kim, Min Woo; Kailasa, Suresh Kumar; Oh, Kyung Taek; Park, Tae Jung
- Issue Date
- Dec-2019
- Publisher
- Royal Society of Chemistry
- Citation
- Biomaterials Science, v.7, no.12, pp 5187 - 5196
- Pages
- 10
- Journal Title
- Biomaterials Science
- Volume
- 7
- Number
- 12
- Start Page
- 5187
- End Page
- 5196
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/37435
- DOI
- 10.1039/c9bm01228a
- ISSN
- 2047-4830
2047-4849
- Abstract
- Photothermal therapy (PTT) is performed using near-infrared-responsive agents, which is proven to be an effective therapeutic strategy against cancer with several advantages including minimal invasion, high effectiveness, and easy implementation. Herein, we report a facile and novel one-pot synthetic approach for the fabrication of polydopamine-folate carbon dots (PFCDs) as theranostic nanocarriers for the image-guided PTT targeting of prostate cancer (PCa) cells that express a prostate-specific membrane antigen (PSMA) (folate hydrolase 1). The as-fabricated PFCDs exhibited several advantages such as easy preparation, high biocompatibility, low toxicity, good water-solubility, and excellent photothermal effect with robust blue fluorescence emission. The PSMA-directed imaging of PCa using PFCDs showed remarkable fluorescence enhancement in LNCap cells as compared to the case of other cells that did not express PSMA. PFCDs exhibited a photothermal effect in the PCa cells when irradiated with an 808 nm laser, which possibly resulted in the complete elimination of the tumor. Thus, these features make PFCDs a promising candidate for PTT. Moreover, PFCD-based PTT provides an effective biomedical platform for cancer therapy. © 2019 The Royal Society of Chemistry.
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