Reducing Agent-Assisted Excessive Galvanic Replacement Mediated Seed-Mediated Synthesis of Porous Gold Nanoplates and Highly Efficient Gene-Thermo Cancer Therapy
- Authors
- Kang, Seounghun; Kang, Kyunglee; Huh, Hyun; Kim, Hyungjun; Chang, Sung-Jin; Park, Tae Jung; Chang, Ki Soo; Min, Dal-Hee; Jang, Hongje
- Issue Date
- Oct-2017
- Publisher
- AMER CHEMICAL SOC
- Keywords
- cancer therapy; galvanic replacement; gene delivery; photothermal therapy; porous nanostructure
- Citation
- ACS APPLIED MATERIALS & INTERFACES, v.9, no.40, pp 35268 - 35278
- Pages
- 11
- Journal Title
- ACS APPLIED MATERIALS & INTERFACES
- Volume
- 9
- Number
- 40
- Start Page
- 35268
- End Page
- 35278
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/3784
- DOI
- 10.1021/acsami.7b13028
- ISSN
- 1944-8244
1944-8252
- Abstract
- Porous Au nanoplates (pAuNPs) were manufactured by a reducing agent-assisted galvanic replacement reaction on Ag nanoplates using a seed-mediated synthetic approach. Two core additives, poly(vinylpyrrolidone) and ,ascorbic acid, prevented fragmentation and proceeded secondary growth. By controlling the concentration of the additives and the amount of replacing ion AuCl4-, various nanostructures including nanoplates with holes, nanoframes, porous nanoplates, and bumpy nanoparticles with unity and homogeneity were synthesized. The present synthetic method is advantageous, because it can be used to manufacture pAuNPs with ease, robustness, and convenience. The prepared pAuNPs exhibited a highly efficient photothermal conversion effect and cargo loading capacity on exposed surfaces by Au-thiol linkage. By using dual cargo mixed loading of the hepatitis C virus (HCV) targeting gene drug DNAzyme and cell-penetrating peptide TAT onto the surface of the pAuNPs and photothermal conversion-mediated hyperthermic treatment, successful gene-thermo therapy against HCV genomic human hepatocarcinoma cells were demonstrated.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Natural Sciences > Department of Chemistry > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/3784)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.