Excimer Emission-Based Fluorescent Probe Targeting Caspase-3
- Authors
- Kim, Tae-I; Jin, Hanyong; Bae, Jeehyeon; Kim, Youngmi
- Issue Date
- Oct-2017
- Publisher
- AMER CHEMICAL SOC
- Citation
- ANALYTICAL CHEMISTRY, v.89, no.19, pp 10565 - 10569
- Pages
- 5
- Journal Title
- ANALYTICAL CHEMISTRY
- Volume
- 89
- Number
- 19
- Start Page
- 10565
- End Page
- 10569
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/3792
- DOI
- 10.1021/acs.analchem.7b02790
- ISSN
- 0003-2700
1520-6882
- Abstract
- A fluorescent probe based on an excimer-forming benzothiazolyl-cyanovinylene (CV) dye was developed to target the apoptotic protease caspase-3. Upon the action of caspase-3, the water-soluble fluorescent probe Ac-DEVDNH-CV, which is weakly green emissive in aqueous solution, is converted to hydrophobic CV-NH2, which spontaneously aggregates. Aggregation of CV-NH2 promotes excimer emission of the CV dye, which allows for the study of caspase-3 activity in vitro and for imaging the activity of the enzyme in living cells because of the large red shift and enhanced fluorescence signal of the probe.
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Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
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